Abstr: This paper introduces the vacuum stirring defoaming machine, which is an efficient defoaming equipment and can easily solve the bubble problem. We will introduce the vacuum stirring defoaming machine from two aspects of principle and working process. Then, we will elaborate on the vacuum stirring defoaming machine in chemical, food, medicine and other fields of application. Next, we will discuss the advantages of vacuum stirring defoaming machines in the material development and production process. We will also discuss the operation precautions and maintenance methods of the vacuum mixing defoaming machine. We will summarize the importance and application prospect of vacuum stirring defoaming machine. The vacuum stirring defoaming machine uses the low pressure under the negative pressure environment to make the bubbles in the liquid escape by stirring and shaking, so as to achieve the purpose of defoaming. The principle is based on the relationship between gas solubility and pressure, which promotes the release of bubbles from the liquid by reducing the ambient pressure. Second, the working process vacuum mixing defoaming machine is mainly composed of vacuum tank, agitator and control system. When working, the liquid to be vacuumed is placed in the vacuum tank, the stirrer and the vacuum pump are started, and the bubbles escape from the liquid through stirring and negative pressure, and are pumped away by the vacuum pump. The vacuum stirring defoaming machine is widely used in the chemical industry in the defoaming process of coating, resin, adhesive and other manufacturing processes. It can effectively remove bubbles and improve product quality and stability. The vacuum stirring defoaming machine is often used in food processing to remove bubbles in liquids such as jam and soy sauce, so that the taste of the product is more delicate and the shelf life is extended. The vacuum stirring defoaming machine plays an important role in the pharmaceutical manufacturing process, which can remove the bubbles in the pharmaceutical liquid and ensure the stability and safety of the drug. Six, material development and application vacuum stirring defoaming machine in the development of materials more and more widely used. It can remove bubbles in the material and improve the compactness and mechanical properties of the material. Seven, the advantages of the production process vacuum stirring defoaming machine has the characteristics of high efficiency, fast and reliable. It can greatly shorten the foaming time and improve production efficiency. When using the vacuum stirring defoaming machine, it is necessary to pay attention to the operation specifications to ensure the safety and normal operation of the equipment. Regular maintenance of the vacuum mixing defoaming machine to maintain the good condition of the equipment and extend the service life. Ten, importance and application prospects Vacuum mixing defoaming machine in many industries have a wide range of applications, its importance can not be ignored. With the development of science and technology, the application prospect of vacuum stirring defoaming machine will be broader. Summary: Vacuum stirring defoaming machine is an efficient defoaming equipment, which can easily solve the problem of bubbles. In this paper, the principle, working process, application field, advantages and precautions of vacuum stirring defoaming machine are described in detail. Vacuum stirring defoaming machine is widely used in chemical, food, medicine and other fields, and has great importance and good application prospect. By using a vacuum stirring defoaming machine, product quality, stability and production efficiency can be improved to meet the needs of different industries.